12,751 research outputs found

    The year 1970-a "modest" beginning for monetary aggregates

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    Monetary policy - United States

    What to Fix? Distinguishing between design and non-design rules in automated tools

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    Technical debt---design shortcuts taken to optimize for delivery speed---is a critical part of long-term software costs. Consequently, automatically detecting technical debt is a high priority for software practitioners. Software quality tool vendors have responded to this need by positioning their tools to detect and manage technical debt. While these tools bundle a number of rules, it is hard for users to understand which rules identify design issues, as opposed to syntactic quality. This is important, since previous studies have revealed the most significant technical debt is related to design issues. Other research has focused on comparing these tools on open source projects, but these comparisons have not looked at whether the rules were relevant to design. We conducted an empirical study using a structured categorization approach, and manually classify 466 software quality rules from three industry tools---CAST, SonarQube, and NDepend. We found that most of these rules were easily labeled as either not design (55%) or design (19%). The remainder (26%) resulted in disagreements among the labelers. Our results are a first step in formalizing a definition of a design rule, in order to support automatic detection.Comment: Long version of accepted short paper at International Conference on Software Architecture 2017 (Gothenburg, SE

    Kettlebell training in clinical practice: a scoping review

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    THE LACK OF A PROFIT MOTIVE FOR RANCHING: IMPLICATIONS FOR POLICY ANALYSIS

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    The economic impact of changing land-use policies has traditionally been estimated using the standard economic model of profit maximization. Ranchers are assumed to maximize profit and to adjust production strategies so as to continue maximizing profit with altered policies. Yet, nearly 30 years of research and observation have shown that family, tradition, and the desirable way of life are the most important factors in the ranch purchase decision - not profit. Ranch buyers want an investment they can touch, feel, and enjoy, and they historically have been willing to accept relatively low returns from the livestock production. Profit maximization appears to be an inadequate model for explaining rancher behavior, describing grazing land use, and estimating the impacts of altered public land policies. In this paper, we investigate the relative importance of livestock production income and desirable lifestyle attributes in determining the market value of western ranches, and we explore what this means for economic models and policy analysis.Agricultural and Food Policy, Land Economics/Use,

    System design of the Pioneer Venus spacecraft. Volume 9: Attitude control/mechanisms subsystems studies

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    The Pioneer Venus mission study was conducted for a probe spacecraft and an orbiter spacecraft to be launched by either a Thor/Delta or an Atlas/Centaur launch vehicle. Both spacecraft are spin stabilized. The spin speed is controlled by ground commands to as low as 5 rpm for science instrument scanning on the orbiter and as high as 71 rpm for small probes released from the probe bus. A major objective in the design of the attitude control and mechanism subsystem (ACMS) was to provide, in the interest of costs, maximum commonality of the elements between the probe bus and orbiter spacecraft configurations. This design study was made considering the use of either launch vehicle. The basic functional requirements of the ACMS are derived from spin axis pointing and spin speed control requirements implicit in the acquisition, cruise, encounter and orbital phases of the Pioneer Venus missions

    Endogenous Nutritive Support after Traumatic Brain Injury: Peripheral Lactate Production for Glucose Supply via Gluconeogenesis.

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    We evaluated the hypothesis that nutritive needs of injured brains are supported by large and coordinated increases in lactate shuttling throughout the body. To that end, we used dual isotope tracer ([6,6-(2)H2]glucose, i.e., D2-glucose, and [3-(13)C]lactate) techniques involving central venous tracer infusion along with cerebral (arterial [art] and jugular bulb [JB]) blood sampling. Patients with traumatic brain injury (TBI) who had nonpenetrating head injuries (n=12, all male) were entered into the study after consent of patients' legal representatives. Written and informed consent was obtained from healthy controls (n=6, including one female). As in previous investigations, the cerebral metabolic rate (CMR) for glucose was suppressed after TBI. Near normal arterial glucose and lactate levels in patients studied 5.7±2.2 days (range of days 2-10) post-injury, however, belied a 71% increase in systemic lactate production, compared with control, that was largely cleared by greater (hepatic+renal) glucose production. After TBI, gluconeogenesis from lactate clearance accounted for 67.1% of glucose rate of appearance (Ra), which was compared with 15.2% in healthy controls. We conclude that elevations in blood glucose concentration after TBI result from a massive mobilization of lactate from corporeal glycogen reserves. This previously unrecognized mobilization of lactate subserves hepatic and renal gluconeogenesis. As such, a lactate shuttle mechanism indirectly makes substrate available for the body and its essential organs, including the brain, after trauma. In addition, when elevations in arterial lactate concentration occur after TBI, lactate shuttling may provide substrate directly to vital organs of the body, including the injured brain

    CMB power spectrum contribution from cosmic strings using field-evolution simulations of the Abelian Higgs model

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    We present the first field-theoretic calculations of the contribution made by cosmic strings to the temperature power spectrum of the cosmic microwave background (CMB). Unlike previous work, in which strings were modeled as idealized one-dimensional objects, we evolve the simplest example of an underlying field theory containing local U(1) strings, the Abelian Higgs model. Limitations imposed by finite computational volumes are overcome using the scaling property of string networks and a further extrapolation related to the lessening of the string width in comoving coordinates. The strings and their decay products, which are automatically included in the field theory approach, source metric perturbations via their energy-momentum tensor, the unequal-time correlation functions of which are used as input into the CMB calculation phase. These calculations involve the use of a modified version of CMBEASY, with results provided over the full range of relevant scales. We find that the string tension μ\mu required to normalize to the WMAP 3-year data at multipole ℓ=10\ell = 10 is Gμ=[2.04±0.06(stat.)±0.12(sys.)]×10−6G\mu = [2.04\pm0.06\textrm{(stat.)}\pm0.12\textrm{(sys.)}] \times 10^{-6}, where we have quoted statistical and systematic errors separately, and GG is Newton's constant. This is a factor 2-3 higher than values in current circulation.Comment: 23 pages, 14 figures; further optimized figures for 1Mb size limit, appendix added before submission to journal, matches accepted versio

    Lactate: brain fuel in human traumatic brain injury: a comparison with normal healthy control subjects.

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    We evaluated the hypothesis that lactate shuttling helps support the nutritive needs of injured brains. To that end, we utilized dual isotope tracer [6,6-(2)H2]glucose, that is, D2-glucose, and [3-(13)C]lactate techniques involving arm vein tracer infusion along with simultaneous cerebral (arterial [art] and jugular bulb [JB]) blood sampling. Traumatic brain injury (TBI) patients with nonpenetrating brain injuries (n=12) were entered into the study following consent of patients' legal representatives. Written and informed consent was obtained from control volunteers (n=6). Patients were studied 5.7±2.2 (mean±SD) days post-injury; during periods when arterial glucose concentration tended to be higher in TBI patients. As in previous investigations, the cerebral metabolic rate for glucose (CMRgluc, i.e., net glucose uptake) was significantly suppressed following TBI (p<0.001). However, lactate fractional extraction, an index of cerebral lactate uptake related to systemic lactate supply, approximated 11% in both healthy control subjects and TBI patients. Further, neither the CMR for lactate (CMRlac, i.e., net lactate release), nor the tracer-measured cerebral lactate uptake differed between healthy controls and TBI patients. The percentages of lactate tracer taken up and released as (13)CO2 into the JB accounted for 92% and 91% for control and TBI conditions, respectively, suggesting that most cerebral lactate uptake was oxidized following TBI. Comparisons of isotopic enrichments of lactate oxidation from infused [3-(13)C]lactate tracer and (13)C-glucose produced during hepatic and renal gluconeogenesis (GNG) showed that 75-80% of (13)CO2 released into the JB was from lactate and that the remainder was from the oxidation of glucose secondarily labeled from lactate. Hence, either directly as lactate uptake, or indirectly via GNG, peripheral lactate production accounted for ∼70% of carbohydrate (direct lactate uptake+uptake of glucose from lactate) consumed by the injured brain. Undiminished cerebral lactate fractional extraction and uptake suggest that arterial lactate supplementation may be used to compensate for decreased CMRgluc following TBI
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